Assay Detail
Binding
CHEMBL4119780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to wild-type human PIK3Calpha (R108 to N1068 residues) expressed in mammalian expression system by KINOMEScan assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential of PI3Kβ Inhibitors in the Treatment of Cancer and Other Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 6.06 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4125781 | — | — | 1 | 7.85 |
| CHEMBL4130282 | — | — | 1 | 7.47 |
| CHEMBL4129062 | — | — | 1 | 6.76 |
| CHEMBL4128507 | — | — | 1 | 6.22 |
| CHEMBL4127425 | — | — | 1 | 6.08 |
| CHEMBL4127822 | — | — | 1 | 5.96 |
| CHEMBL4127570 | — | — | 1 | 5.72 |
| CHEMBL4127116 | — | — | 1 | 5.60 |
| CHEMBL4128821 | — | — | 1 | 5.24 |
| CHEMBL4127012 | — | — | 1 | 4.91 |
| CHEMBL4129223 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4125781 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL4130282 | — | Kd | = | 34.0 | nM | 7.47 |
| CHEMBL4129062 | — | Kd | = | 174.0 | nM | 6.76 |
| CHEMBL4128507 | — | Kd | = | 599.0 | nM | 6.22 |
| CHEMBL4127425 | — | Kd | = | 832.0 | nM | 6.08 |
| CHEMBL4127822 | — | Kd | = | 1105.0 | nM | 5.96 |
| CHEMBL4127570 | — | Kd | = | 1905.0 | nM | 5.72 |
| CHEMBL4127116 | — | Kd | = | 2512.0 | nM | 5.60 |
| CHEMBL4128821 | — | Kd | = | 5754.0 | nM | 5.24 |
| CHEMBL4127012 | — | Kd | = | 12276.0 | nM | 4.91 |
| CHEMBL4129223 | — | Kd | = | 14232.0 | nM | 4.85 |