Assay Detail
Binding
CHEMBL4119785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta in human PC3 cells assessed as reduction in AKT phosphorylation at S473 residue measured after 60 mins by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential of PI3Kβ Inhibitors in the Treatment of Cancer and Other Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.02 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4130282 | — | — | 1 | 8.70 |
| CHEMBL4128507 | — | — | 1 | 8.70 |
| CHEMBL4129062 | — | — | 1 | 8.40 |
| CHEMBL4127116 | — | — | 1 | 8.22 |
| CHEMBL4125781 | — | — | 1 | 8.15 |
| CHEMBL4127425 | — | — | 1 | 8.15 |
| CHEMBL4127570 | — | — | 1 | 8.05 |
| CHEMBL4127822 | — | — | 1 | 7.31 |
| CHEMBL4128821 | — | — | 1 | 6.48 |
| CHEMBL4127012 | — | — | 1 | - |
| CHEMBL4129223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4130282 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4128507 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4129062 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4127116 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4125781 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4127425 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4127570 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4127822 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4128821 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL4127012 | — | IC50 | > | 513.0 | nM | - |
| CHEMBL4129223 | — | IC50 | > | 513.0 | nM | - |