Assay Detail
Binding
CHEMBL4119868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-based assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 12 (CHEMBL1908389) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.35 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128619 | — | — | 1 | 7.00 |
| CHEMBL3715238 | — | — | 1 | 6.84 |
| CHEMBL3718522 | — | — | 1 | 6.75 |
| CHEMBL3719135 | — | — | 1 | 6.71 |
| CHEMBL4128477 | — | — | 1 | 6.70 |
| CHEMBL3714822 | — | — | 1 | 6.68 |
| CHEMBL4128889 | — | — | 1 | 6.68 |
| CHEMBL3717481 | — | — | 1 | 6.60 |
| CHEMBL3716231 | — | — | 1 | 6.58 |
| CHEMBL4125824 | — | — | 1 | 6.56 |
| CHEMBL4125721 | — | — | 1 | 6.52 |
| CHEMBL3718912 | — | — | 1 | 6.52 |
| CHEMBL3718265 | — | — | 1 | 6.52 |
| CHEMBL3714987 | — | — | 1 | 6.48 |
| CHEMBL4129958 | — | — | 1 | 6.39 |
| CHEMBL3718344 | — | — | 1 | 6.31 |
| CHEMBL3716456 | — | — | 1 | 6.24 |
| CHEMBL3717769 | — | — | 1 | 6.21 |
| CHEMBL4127238 | — | — | 1 | 6.08 |
| CHEMBL3715469 | — | — | 1 | 6.06 |
| CHEMBL3717627 | — | — | 1 | 5.92 |
| CHEMBL4127922 | — | — | 1 | 5.89 |
| CHEMBL3718750 | — | — | 1 | 5.77 |
| CHEMBL4126530 | — | — | 1 | 5.75 |
| CHEMBL3719126 | — | — | 1 | 5.72 |
| CHEMBL3719209 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128619 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3715238 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL3718522 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3719135 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4128477 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL3714822 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4128889 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3717481 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3716231 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL4125824 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL4125721 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL3718912 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL3718265 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL3714987 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL4129958 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL3718344 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL3716456 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL3717769 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL4127238 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL3715469 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL3717627 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4127922 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3718750 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4126530 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3719126 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3719209 | — | IC50 | = | 2800.0 | nM | 5.55 |