Assay Detail
Binding
CHEMBL4121237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AVP from human liver vasopressin V1a receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.09 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 8.70 |
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 7.70 |
| CHEMBL4126100 | — | — | 1 | 7.52 |
| CHEMBL4127791 | — | — | 1 | 7.16 |
| CHEMBL4129142 | — | — | 1 | 5.77 |
| CHEMBL4128839 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL395429 | OXYTOCIN | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4126100 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4127791 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL4129142 | — | Ki | = | 1681.0 | nM | 5.77 |
| CHEMBL4128839 | — | Ki | = | 1954.0 | nM | 5.71 |