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Compound Detail

CHEMBL4128839

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CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccc(cc2)SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O

Basic Information

ChEMBL ID CHEMBL4128839
Phase Preclinical
Structure Type MOL
InChI Key NKSOIRAZKJHNSQ-SXXMFYQFSA-N
4
Targets
6
Activities
3
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

1082.3
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C50H71N11O12S2
MW 1082.32

Activity Summary

EC50 3 meas. best 6.96
Ki 2 meas. best 6.85
IC50 1 meas. best 5.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL2049
EC50 6.96 6.96 109.0 1
Oxytocin receptor
CHEMBL2049
Ki 6.85 6.85 142.0 1
Vasopressin V1a receptor
CHEMBL1889
Ki 5.71 5.71 1954.0 1
Vasopressin V1b receptor
CHEMBL1921
EC50 5.65 5.65 2223.0 1
Vasopressin V2 receptor
CHEMBL1790
EC50 5.43 5.43 3669.0 1
Vasopressin V1a receptor
CHEMBL1889
IC50 5.1 5.1 7862.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29602673 10.1016/j.bmc.2018.03.019 Vasopressin V1a receptor 3
29602673 10.1016/j.bmc.2018.03.019 Vasopressin V1b receptor 3
29602673 10.1016/j.bmc.2018.03.019 Vasopressin V2 receptor 3
29602673 10.1016/j.bmc.2018.03.019 Oxytocin receptor 3
29602673 10.1016/j.bmc.2018.03.019 Unchecked 3

Data from ChEMBL 36 via Core Engine