Assay Detail
Binding
CHEMBL4121240
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Displacement of [3H]OT from human mammary gland oxytocin receptor expressed in HEK293 cell membrane after 1 hr by scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.46 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 8.92 |
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 8.22 |
| CHEMBL4129142 | — | — | 1 | 7.30 |
| CHEMBL4128839 | — | — | 1 | 6.85 |
| CHEMBL4126100 | — | — | 1 | 6.78 |
| CHEMBL4127791 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL373742 | VASOPRESSIN | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4129142 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4128839 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL4126100 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL4127791 | — | Ki | = | 220.0 | nM | 6.66 |