Assay Detail
Functional
CHEMBL4121243
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Agonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.62 | 9.52 |
| %max | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 9.52 |
| CHEMBL4129142 | — | — | 2 | 7.47 |
| CHEMBL4128839 | — | — | 1 | 6.96 |
| CHEMBL4127791 | — | — | 1 | 6.53 |
| CHEMBL4126100 | — | — | 1 | - |
| CHEMBL3301668 | CARBETOCIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4129142 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4128839 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4127791 | — | EC50 | = | 294.0 | nM | 6.53 |
| CHEMBL4129142 | — | %max | = | 75.0 | % | - |
| CHEMBL4126100 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3301668 | CARBETOCIN | %max | = | 45.0 | % | - |