Assay Detail
Functional
CHEMBL4121246
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Agonist activity at human kidney vasopressin V2 receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 5 mins by Fluo-4-AM dye based FLIPR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.61 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 7.54 |
| CHEMBL4128839 | — | — | 1 | 5.43 |
| CHEMBL4129142 | — | — | 1 | 5.41 |
| CHEMBL4127791 | — | — | 1 | 4.97 |
| CHEMBL4126100 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4128839 | — | EC50 | = | 3669.0 | nM | 5.43 |
| CHEMBL4129142 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4127791 | — | EC50 | = | 10764.0 | nM | 4.97 |
| CHEMBL4126100 | — | EC50 | = | 18919.0 | nM | 4.72 |