Assay Detail
Binding
CHEMBL4121615
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Inhibition of Staphylococcus aureus SrtA deltaN24 mutant transpeptidation activity using abz-LPATG-dnp as substrate preincubated for 10 mins followed by substrate addition measured every 2 mins for 20 mins by FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Quinone skeleton as a new class of irreversible inhibitors against Staphylococcus aureus sortase A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.72 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | — | 1 | 6.52 |
| CHEMBL4127840 | — | — | 1 | 6.44 |
| CHEMBL4125701 | — | — | 1 | 5.21 |
| CHEMBL4129079 | — | — | 1 | 4.71 |
| CHEMBL4127684 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4127840 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4125701 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4129079 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4127684 | — | IC50 | > | 50000.0 | nM | - |