Assay Detail
Binding
CHEMBL4121734
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Inhibition of IKK1 (unknown origin)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHEMBL3476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.63 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128114 | — | — | 1 | 7.50 |
| CHEMBL4125774 | — | — | 1 | 7.10 |
| CHEMBL4127140 | — | — | 1 | 7.10 |
| CHEMBL4125907 | — | — | 1 | 7.10 |
| CHEMBL4128939 | — | — | 1 | 7.00 |
| CHEMBL4126740 | — | — | 1 | 6.90 |
| CHEMBL4126095 | — | — | 1 | 6.90 |
| CHEMBL4130310 | — | — | 1 | 6.90 |
| CHEMBL4129362 | — | — | 1 | 6.80 |
| CHEMBL4127977 | — | — | 1 | 6.80 |
| CHEMBL4129791 | — | — | 1 | 6.80 |
| CHEMBL4128717 | — | — | 1 | 6.80 |
| CHEMBL4127479 | — | — | 1 | 6.70 |
| CHEMBL4126511 | — | — | 1 | 5.60 |
| CHEMBL4128577 | — | — | 1 | 5.60 |
| CHEMBL4128459 | — | — | 1 | 5.60 |
| CHEMBL4127330 | — | — | 1 | 5.50 |
| CHEMBL4129941 | — | — | 1 | - |
| CHEMBL4127076 | — | — | 1 | - |
| CHEMBL4128540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128114 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL4125774 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4127140 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4125907 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4128939 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4126740 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4126095 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4130310 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4129362 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4127977 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4129791 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4128717 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4127479 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4126511 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4128577 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4128459 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4127330 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4129941 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL4127076 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL4128540 | — | IC50 | > | 25118.86 | nM | - |