Assay Detail
Binding
CHEMBL4121748
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Inhibition of recombinant Bacillus cereus BC2 expressed in Escherichia coli BL21 (DE3) cells using FC4-FC5 as substrate by fluorescence-based assay
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus cereus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 5.69 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4127821 | — | — | 1 | 7.22 |
| CHEMBL4127736 | — | — | 1 | 7.16 |
| CHEMBL3792857 | — | — | 1 | 7.10 |
| CHEMBL3234727 | — | — | 1 | 7.00 |
| CHEMBL4125829 | — | — | 1 | 7.00 |
| CHEMBL4129411 | — | — | 1 | 6.70 |
| CHEMBL1559342 | — | — | 1 | 6.70 |
| CHEMBL4128221 | — | — | 1 | 6.70 |
| CHEMBL4068716 | — | — | 1 | 6.52 |
| CHEMBL4126465 | — | — | 1 | 6.52 |
| CHEMBL4129450 | — | — | 1 | 6.22 |
| CHEMBL4129233 | — | — | 1 | 6.16 |
| CHEMBL4095898 | — | — | 1 | 6.16 |
| CHEMBL3221923 | — | — | 1 | 6.05 |
| CHEMBL4125695 | — | — | 1 | 6.00 |
| CHEMBL4128976 | — | — | 1 | 5.96 |
| CHEMBL4126979 | — | — | 1 | 5.85 |
| CHEMBL4125965 | — | — | 1 | 5.80 |
| CHEMBL4129222 | — | — | 1 | 5.70 |
| CHEMBL4129039 | — | — | 1 | 5.62 |
| CHEMBL4127204 | — | — | 1 | 5.52 |
| CHEMBL4126927 | — | — | 1 | 5.51 |
| CHEMBL4126589 | — | — | 1 | 5.46 |
| CHEMBL3221922 | — | — | 1 | 5.40 |
| CHEMBL3221924 | — | — | 1 | 5.24 |
| CHEMBL3221925 | — | — | 1 | 5.20 |
| CHEMBL4130192 | — | — | 1 | 5.14 |
| CHEMBL3221930 | — | — | 1 | 5.09 |
| CHEMBL3221932 | — | — | 1 | 5.00 |
| CHEMBL4129315 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4127821 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4127736 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3792857 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3234727 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4125829 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4129411 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1559342 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4128221 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4068716 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4126465 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4129450 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4129233 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4095898 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3221923 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4125695 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4128976 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4126979 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4125965 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4129222 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4129039 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4127204 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4126927 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4126589 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3221922 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3221924 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3221925 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4130192 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3221930 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3221932 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4129315 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4126663 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4128032 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL4129749 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4129136 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL1451326 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL4127980 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4126798 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4126745 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL4126780 | — | IC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL1631303 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4128178 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4125789 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1173347 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4127836 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4126149 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4127551 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4126874 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL66070 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2062754 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4129281 | — | IC50 | > | 50000.0 | nM | - |