Assay Detail
Binding
CHEMBL4121774
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Inhibition of human p70S6K measured at apparent ATP Km level
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.81 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545076 | LY-2584702 | 1.0 | 1 | 8.40 |
| CHEMBL4128457 | — | — | 1 | 7.46 |
| CHEMBL4129379 | — | — | 1 | 6.40 |
| CHEMBL4129817 | — | — | 1 | 6.06 |
| CHEMBL4126067 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545076 | LY-2584702 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4128457 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4129379 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL4129817 | — | IC50 | = | 876.0 | nM | 6.06 |
| CHEMBL4126067 | — | IC50 | = | 1900.0 | nM | 5.72 |