Compound Detail
CHEMBL4128457
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C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(-c5ccc(F)c(C(F)(F)F)c5)cn4CCN4CCCC4)CC3)c21
Basic Information
| ChEMBL ID | CHEMBL4128457 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XIYKGCYSJCRNDN-GOSISDBHSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
571.6
MW (Da)
5.42
ALogP
7
HBA
1
HBD
79.2
PSA (Ų)
0.40
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 8.52 | 7.965 | 3.0 | 2 |
| Ribosomal protein S6 kinase alpha-1 CHEMBL2553 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Ribosomal protein S6 kinase beta-1 CHEMBL4501 | IC50 | 7.46 | 7.46 | 35.0 | 1 |
| Protein kinase C beta type CHEMBL3045 | IC50 | 7.44 | 7.44 | 36.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.18 | 6.18 | 653.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 3.0 | nM | 8.52 | Inhibition of human recombinant AKT1 expressed in insect cells incubated for 60 ... | 29655979 |
| Ribosomal protein S6 kinase alpha-1 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of human RSK1 measured at apparent ATP Km level | 29655979 |
| Ribosomal protein S6 kinase beta-1 | IC50 | = | 35.0 | nM | 7.46 | Inhibition of human p70S6K measured at apparent ATP Km level | 29655979 |
| Protein kinase C beta type | IC50 | = | 36.0 | nM | 7.44 | Inhibition of human PKCbeta2 measured at apparent ATP Km level | 29655979 |
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 39.0 | nM | 7.41 | Inhibition of AKT1 in human U87MG cells assessed as reduction in GSK3beta Ser9 p... | 29655979 |
| Unchecked | IC50 | = | 653.0 | nM | 6.18 | Inhibition of human PKA measured at apparent ATP Km level | 29655979 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29655979 | 10.1016/j.bmcl.2018.03.092 | No relevant target | 2 |
| 29655979 | 10.1016/j.bmcl.2018.03.092 | RAC-alpha serine/threonine-protein kinase | 2 |
| 29655979 | 10.1016/j.bmcl.2018.03.092 | Unchecked | 2 |
| 29655979 | 10.1016/j.bmcl.2018.03.092 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 29655979 | 10.1016/j.bmcl.2018.03.092 | Ribosomal protein S6 kinase beta-1 | 1 |
| 29655979 | 10.1016/j.bmcl.2018.03.092 | Rho-associated protein kinase 2 | 1 |
| 29655979 | 10.1016/j.bmcl.2018.03.092 | Protein kinase C beta type | 1 |
| 29655979 | 10.1016/j.bmcl.2018.03.092 | Ribosomal protein S6 kinase alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine