Assay Detail
Binding
CHEMBL4121776
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Inhibition of human PKA measured at apparent ATP Km level
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.64 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4129379 | — | — | 1 | 7.08 |
| CHEMBL4129817 | — | — | 1 | 6.91 |
| CHEMBL4126067 | — | — | 1 | 6.38 |
| CHEMBL4128457 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4129379 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4129817 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4126067 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL4128457 | — | IC50 | = | 653.0 | nM | 6.18 |