Assay Detail
Binding
CHEMBL4121773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant AKT1 expressed in insect cells incubated for 60 mins measured at apparent ATP Km level by kinase ADP-FP assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.30 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128457 | — | — | 1 | 8.52 |
| CHEMBL4126067 | — | — | 1 | 8.40 |
| CHEMBL4129379 | — | — | 1 | 8.30 |
| CHEMBL4129817 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128457 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4126067 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4129379 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4129817 | — | IC50 | = | 11.0 | nM | 7.96 |