Assay Detail
Binding
CHEMBL4121777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PKCbeta2 measured at apparent ATP Km level
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.58 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128457 | — | — | 1 | 7.44 |
| CHEMBL4129379 | — | — | 1 | 5.40 |
| CHEMBL4129817 | — | — | 1 | 4.79 |
| CHEMBL4126067 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128457 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4129379 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL4129817 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4126067 | — | IC50 | = | 20000.0 | nM | 4.70 |