Assay Detail
Binding
CHEMBL4121951
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of allosterically sensitized mutant form of His6-tagged human HePTP catalytic domain using pNPP as substrate incubated for 90 mins by quenched phosphatase activity assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 7 (CHEMBL2219) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 6.90 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454668 | — | — | 2 | 6.90 |
| CHEMBL4128595 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454668 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL454668 | — | Inhibition | - | % | - | |
| CHEMBL4128595 | — | Inhibition | - | % | - |