Assay Detail
Functional
CHEMBL4122014
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Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562/VCR |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and antineoplastic activity of novel hybrids of podophyllotoxin and indirubin against human leukaemia cancer cells as multifunctional anti-MDR agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.74 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.30 |
| CHEMBL4125872 | — | — | 1 | 7.12 |
| CHEMBL4129576 | — | — | 1 | 5.76 |
| CHEMBL4129174 | — | — | 1 | 5.67 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 5.32 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.93 |
| CHEMBL4128204 | — | — | 1 | 4.07 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4125872 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4129576 | — | IC50 | = | 1748.0 | nM | 5.76 |
| CHEMBL4129174 | — | IC50 | = | 2142.0 | nM | 5.67 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 4737.0 | nM | 5.32 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 11840.0 | nM | 4.93 |
| CHEMBL4128204 | — | IC50 | = | 85733.0 | nM | 4.07 |
| CHEMBL1276127 | INDIRUBIN | IC50 | > | 100000.0 | nM | - |