Assay Detail
Binding
CHEMBL4122262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Boc-QRR-AMC as substrate after 15 mins by automated fluorescence assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.98 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 8.30 |
| CHEMBL590799 | CAMOSTAT | 3.0 | 1 | 7.54 |
| CHEMBL4130135 | — | — | 1 | 7.48 |
| CHEMBL4128554 | — | — | 1 | 7.05 |
| CHEMBL4126579 | — | — | 1 | 7.00 |
| CHEMBL48233 | — | — | 1 | 6.57 |
| CHEMBL4125890 | — | — | 1 | 6.52 |
| CHEMBL87563 | GABEXATE | 3.0 | 1 | 6.42 |
| CHEMBL4128130 | — | — | 1 | 6.30 |
| CHEMBL4129512 | — | — | 1 | 6.22 |
| CHEMBL4127452 | — | — | 1 | 6.17 |
| CHEMBL4128356 | — | — | 1 | 6.17 |
| CHEMBL4127961 | — | — | 1 | 6.16 |
| CHEMBL4126905 | — | — | 1 | 6.07 |
| CHEMBL4128098 | — | — | 1 | 6.05 |
| CHEMBL4129196 | — | — | 1 | 5.96 |
| CHEMBL4128512 | — | — | 1 | 5.95 |
| CHEMBL4130324 | — | — | 1 | 5.85 |
| CHEMBL4127050 | — | — | 1 | 5.82 |
| CHEMBL4128139 | — | — | 1 | 5.75 |
| CHEMBL4128515 | — | — | 1 | 5.70 |
| CHEMBL4126981 | — | — | 1 | 5.52 |
| CHEMBL423699 | — | — | 1 | 5.50 |
| CHEMBL4129630 | — | — | 1 | 5.47 |
| CHEMBL4127274 | — | — | 1 | 5.40 |
| CHEMBL51173 | — | — | 1 | 5.35 |
| CHEMBL4130180 | — | — | 1 | 5.30 |
| CHEMBL143594 | — | — | 1 | 5.21 |
| CHEMBL107627 | — | — | 1 | 5.18 |
| CHEMBL4127304 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL590799 | CAMOSTAT | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4130135 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4128554 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4126579 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL48233 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL4125890 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL87563 | GABEXATE | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL4128130 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4129512 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4127452 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4128356 | — | IC50 | = | 676.0 | nM | 6.17 |
| CHEMBL4127961 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4126905 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4128098 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4129196 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4128512 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4130324 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4127050 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4128139 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4128515 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4126981 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL423699 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4129630 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL4127274 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL51173 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL4130180 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL143594 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL107627 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL4127304 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4126725 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL4126876 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL4125818 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL140413 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129480 | — | IC50 | > | 10000.0 | nM | - |