Compound Detail
CHEMBL4130324
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Basic Information
| ChEMBL ID | CHEMBL4130324 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XSKXVYZHSAFULW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
430.5
MW (Da)
1.99
ALogP
5
HBA
4
HBD
134.4
PSA (Ų)
0.39
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine protease hepsin CHEMBL2079849 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine protease hepsin | IC50 | = | 1400.0 | nM | 5.85 | Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 resid... | 29701962 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29701962 | 10.1021/acs.jmedchem.7b01698 | Serine protease hepsin | 1 |
| 29701962 | 10.1021/acs.jmedchem.7b01698 | Urokinase-type plasminogen activator | 1 |
| 29701962 | 10.1021/acs.jmedchem.7b01698 | Unchecked | 1 |
| 29701962 | 10.1021/acs.jmedchem.7b01698 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine