Assay Detail
Functional
CHEMBL4122688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 8.14 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.92 |
| CHEMBL4128200 | — | — | 1 | 9.46 |
| CHEMBL4126644 | — | — | 1 | 9.44 |
| CHEMBL4128689 | — | — | 1 | 9.24 |
| CHEMBL4130230 | — | — | 1 | 9.22 |
| CHEMBL4129170 | — | — | 1 | 9.14 |
| CHEMBL4127774 | — | — | 1 | 9.12 |
| CHEMBL4126818 | — | — | 1 | 8.92 |
| CHEMBL4125762 | — | — | 1 | 8.81 |
| CHEMBL4129917 | — | — | 1 | 7.83 |
| CHEMBL4129051 | — | — | 1 | 7.54 |
| CHEMBL4126486 | — | — | 1 | 7.46 |
| CHEMBL4125732 | — | — | 1 | 7.28 |
| CHEMBL4128838 | — | — | 1 | 7.21 |
| CHEMBL4130176 | — | — | 1 | 7.03 |
| CHEMBL4130059 | — | — | 1 | 6.84 |
| CHEMBL4127877 | — | — | 1 | 6.25 |
| CHEMBL4127445 | — | — | 1 | 5.81 |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | - |
| CHEMBL4126958 | — | — | 1 | - |
| CHEMBL4129019 | — | — | 1 | - |
| CHEMBL4126912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4128200 | — | EC50 | = | 0.35 | nM | 9.46 |
| CHEMBL4126644 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL4128689 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL4130230 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4129170 | — | EC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4127774 | — | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL4126818 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4125762 | — | EC50 | = | 1.55 | nM | 8.81 |
| CHEMBL4129917 | — | EC50 | = | 14.93 | nM | 7.83 |
| CHEMBL4129051 | — | EC50 | = | 28.8 | nM | 7.54 |
| CHEMBL4126486 | — | EC50 | = | 34.98 | nM | 7.46 |
| CHEMBL4125732 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4128838 | — | EC50 | = | 62.43 | nM | 7.21 |
| CHEMBL4130176 | — | EC50 | = | 93.37 | nM | 7.03 |
| CHEMBL4130059 | — | EC50 | = | 146.01 | nM | 6.84 |
| CHEMBL4127877 | — | EC50 | = | 567.0 | nM | 6.25 |
| CHEMBL4127445 | — | EC50 | = | 1563.21 | nM | 5.81 |
| CHEMBL95 | TACRINE | EC50 | - | — | - | |
| CHEMBL395280 | HUPERZINE A | EC50 | - | — | - | |
| CHEMBL4126958 | — | EC50 | < | 0.14 | nM | - |
| CHEMBL4129019 | — | EC50 | < | 0.14 | nM | - |
| CHEMBL4126912 | — | EC50 | > | 10000.0 | nM | - |