Assay Detail
Binding
CHEMBL4122689
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Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 20 mins by by Ellman's method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.65 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 6.92 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.89 |
| CHEMBL4130230 | — | — | 1 | 5.95 |
| CHEMBL4128838 | — | — | 1 | 5.87 |
| CHEMBL4126818 | — | — | 1 | 5.84 |
| CHEMBL4126958 | — | — | 1 | 5.79 |
| CHEMBL4126644 | — | — | 1 | 5.76 |
| CHEMBL4125732 | — | — | 1 | 5.74 |
| CHEMBL4127877 | — | — | 1 | 5.70 |
| CHEMBL4126912 | — | — | 1 | 5.68 |
| CHEMBL4129019 | — | — | 1 | 5.65 |
| CHEMBL4125762 | — | — | 1 | 5.63 |
| CHEMBL4128689 | — | — | 1 | 5.63 |
| CHEMBL4127445 | — | — | 1 | 5.54 |
| CHEMBL4126486 | — | — | 1 | 5.48 |
| CHEMBL4129051 | — | — | 1 | 5.29 |
| CHEMBL4130176 | — | — | 1 | 5.25 |
| CHEMBL4129917 | — | — | 1 | 4.99 |
| CHEMBL4130059 | — | — | 1 | 4.74 |
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 4.67 |
| CHEMBL4129170 | — | — | 1 | - |
| CHEMBL4127774 | — | — | 1 | - |
| CHEMBL4128200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL95 | TACRINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4130230 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4128838 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4126818 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4126958 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4126644 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4125732 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL4127877 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4126912 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4129019 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4125762 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4128689 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL4127445 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL4126486 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL4129051 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4130176 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL4129917 | — | IC50 | = | 10240.0 | nM | 4.99 |
| CHEMBL4130059 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL439849 | VILAZODONE | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL4129170 | — | IC50 | - | — | - | |
| CHEMBL4127774 | — | IC50 | - | — | - | |
| CHEMBL4128200 | — | IC50 | - | — | - |