Assay Detail
Binding
CHEMBL4122690
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Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate after 20 mins by by Ellman's method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.30 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.10 |
| CHEMBL4128689 | — | — | 1 | 7.00 |
| CHEMBL4130059 | — | — | 1 | 6.64 |
| CHEMBL4129051 | — | — | 1 | 6.60 |
| CHEMBL4127445 | — | — | 1 | 6.60 |
| CHEMBL4125762 | — | — | 1 | 6.51 |
| CHEMBL4126644 | — | — | 1 | 6.47 |
| CHEMBL4130230 | — | — | 1 | 6.44 |
| CHEMBL4127877 | — | — | 1 | 6.43 |
| CHEMBL4128838 | — | — | 1 | 6.41 |
| CHEMBL4126818 | — | — | 1 | 6.41 |
| CHEMBL4126958 | — | — | 1 | 6.40 |
| CHEMBL4129019 | — | — | 1 | 6.39 |
| CHEMBL4125732 | — | — | 1 | 6.38 |
| CHEMBL4129917 | — | — | 1 | 6.19 |
| CHEMBL4126912 | — | — | 1 | 5.95 |
| CHEMBL4126486 | — | — | 1 | 5.73 |
| CHEMBL4130176 | — | — | 1 | 5.54 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 4.44 |
| CHEMBL4128200 | — | — | 1 | - |
| CHEMBL4127774 | — | — | 1 | - |
| CHEMBL4129170 | — | — | 1 | - |
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4128689 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4130059 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4129051 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4127445 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4125762 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4126644 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4130230 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4127877 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4128838 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4126818 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4126958 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4129019 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4125732 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4129917 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4126912 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4126486 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4130176 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL4128200 | — | IC50 | - | — | - | |
| CHEMBL4127774 | — | IC50 | - | — | - | |
| CHEMBL4129170 | — | IC50 | - | — | - | |
| CHEMBL439849 | VILAZODONE | IC50 | - | — | - |