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Assay Detail

CHEMBL4122822

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Functional
Antiproliferative activity against human Toledo cells after 48 hrs by CCK8 assay
ChEMBL ↗
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Toledo
Confidence 1 — Organism
Curated By Intermediate

Target

Toledo (CHEMBL4296505) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structure-activity relationship studies of MI-2 analogues as MALT1 inhibitors.
Wu G, Wang H, Zhou W, Zeng B, Mo W, Zhu K, Liu R, Zhou J, Chen C, Chen H.
Bioorg Med Chem (2018) 26 : 3321 -3344
PubMed 29751989 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 69 6.12 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4126153 — — 1 6.52
CHEMBL4128426 — — 1 6.51
CHEMBL4126873 — — 1 6.50
CHEMBL4126269 — — 1 6.47
CHEMBL4126531 — — 1 6.47
CHEMBL4126825 — — 1 6.43
CHEMBL4128259 — — 1 6.43
CHEMBL4126430 — — 1 6.42
CHEMBL4129327 — — 1 6.42
CHEMBL4128912 — — 1 6.42
CHEMBL4128258 — — 1 6.41
CHEMBL4129194 — — 1 6.41
CHEMBL4128751 — — 1 6.40
CHEMBL4129713 — — 1 6.40
CHEMBL4129452 — — 1 6.40
CHEMBL4126543 — — 1 6.40
CHEMBL4127191 — — 1 6.40
CHEMBL4128296 — — 1 6.39
CHEMBL4129322 — — 1 6.38
CHEMBL4129292 — — 1 6.37
CHEMBL4129820 — — 1 6.37
CHEMBL4129680 — — 1 6.37
CHEMBL4130298 — — 1 6.37
CHEMBL4125888 — — 1 6.36
CHEMBL4125698 — — 1 6.35
CHEMBL4127504 — — 1 6.34
CHEMBL4126422 — — 1 6.34
CHEMBL4127778 — — 1 6.33
CHEMBL4128903 — — 1 6.33
CHEMBL4126394 — — 1 6.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4126153 — IC50 = 300.0 nM 6.52
CHEMBL4128426 — IC50 = 310.0 nM 6.51
CHEMBL4126873 — IC50 = 320.0 nM 6.50
CHEMBL4126269 — IC50 = 340.0 nM 6.47
CHEMBL4126531 — IC50 = 340.0 nM 6.47
CHEMBL4126825 — IC50 = 370.0 nM 6.43
CHEMBL4128259 — IC50 = 370.0 nM 6.43
CHEMBL4126430 — IC50 = 380.0 nM 6.42
CHEMBL4129327 — IC50 = 380.0 nM 6.42
CHEMBL4128912 — IC50 = 380.0 nM 6.42
CHEMBL4128258 — IC50 = 390.0 nM 6.41
CHEMBL4129194 — IC50 = 390.0 nM 6.41
CHEMBL4129452 — IC50 = 400.0 nM 6.40
CHEMBL4129713 — IC50 = 400.0 nM 6.40
CHEMBL4128751 — IC50 = 400.0 nM 6.40
CHEMBL4126543 — IC50 = 400.0 nM 6.40
CHEMBL4127191 — IC50 = 400.0 nM 6.40
CHEMBL4128296 — IC50 = 410.0 nM 6.39
CHEMBL4129322 — IC50 = 420.0 nM 6.38
CHEMBL4129292 — IC50 = 430.0 nM 6.37
CHEMBL4129820 — IC50 = 430.0 nM 6.37
CHEMBL4129680 — IC50 = 430.0 nM 6.37
CHEMBL4130298 — IC50 = 430.0 nM 6.37
CHEMBL4125888 — IC50 = 440.0 nM 6.36
CHEMBL4125698 — IC50 = 450.0 nM 6.35
CHEMBL4127504 — IC50 = 460.0 nM 6.34
CHEMBL4126422 — IC50 = 460.0 nM 6.34
CHEMBL4127778 — IC50 = 470.0 nM 6.33
CHEMBL4128903 — IC50 = 470.0 nM 6.33
CHEMBL4126394 — IC50 = 490.0 nM 6.31
CHEMBL4127957 — IC50 = 500.0 nM 6.30
CHEMBL4127498 — IC50 = 510.0 nM 6.29
CHEMBL4128179 — IC50 = 530.0 nM 6.28
CHEMBL4126691 — IC50 = 590.0 nM 6.23
CHEMBL4126334 — IC50 = 600.0 nM 6.22
CHEMBL4127639 — IC50 = 610.0 nM 6.21
CHEMBL4126544 — IC50 = 690.0 nM 6.16
CHEMBL4130220 — IC50 = 690.0 nM 6.16
CHEMBL4127021 — IC50 = 720.0 nM 6.14
CHEMBL4129246 — IC50 = 750.0 nM 6.12
CHEMBL4129714 — IC50 = 750.0 nM 6.12
CHEMBL4126949 — IC50 = 770.0 nM 6.11
CHEMBL3183233 — IC50 = 800.0 nM 6.10
CHEMBL4128896 — IC50 = 810.0 nM 6.09
CHEMBL4126170 — IC50 = 860.0 nM 6.07
CHEMBL4128330 — IC50 = 960.0 nM 6.02
CHEMBL4128739 — IC50 = 980.0 nM 6.01
CHEMBL4129819 — IC50 = 1110.0 nM 5.96
CHEMBL4128160 — IC50 = 1470.0 nM 5.83
CHEMBL4129020 — IC50 = 1560.0 nM 5.81