Assay Detail
Binding
CHEMBL4123712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Norovirus prototypic GII.4 3CL protease using HiLyte Fluor 488-labelled DFELQGPK as substrate incubated for 90 mins measured every mins for 20 mins by FRET assay
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Norovirus GII.4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Protease (CHEMBL4295547) ↗| Type | SINGLE PROTEIN |
| Organism | Norovirus Hu/GII.4-2002/WeertE022/2002/NL |
Publication
Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.99 | 7.22 |
| IC90 | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441741 | — | — | 2 | 7.22 |
| CHEMBL4129318 | — | — | 2 | 6.82 |
| CHEMBL4128485 | — | — | 2 | 6.30 |
| CHEMBL4128616 | — | — | 2 | 5.93 |
| CHEMBL4128223 | — | — | 2 | 5.58 |
| CHEMBL4127236 | — | — | 2 | 5.58 |
| CHEMBL4128073 | — | — | 2 | 4.52 |
| CHEMBL4125865 | — | — | 2 | - |
| CHEMBL4127247 | — | — | 2 | - |
| CHEMBL4126005 | — | — | 2 | - |
| CHEMBL4129451 | — | — | 2 | - |
| CHEMBL4126846 | — | — | 2 | - |
| CHEMBL4127374 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441741 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4129318 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4128485 | — | IC50 | = | 502.0 | nM | 6.30 |
| CHEMBL4128616 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4128223 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL4127236 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL4128073 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4125865 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4127247 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4126005 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4129451 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4126846 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4127374 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2441741 | — | IC90 | = | 205.0 | nM | - |
| CHEMBL4128485 | — | IC90 | = | 5540.0 | nM | - |
| CHEMBL4125865 | — | IC90 | - | — | - | |
| CHEMBL4127247 | — | IC90 | - | — | - | |
| CHEMBL4129318 | — | IC90 | = | 1190.0 | nM | - |
| CHEMBL4126005 | — | IC90 | - | — | - | |
| CHEMBL4128073 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL4129451 | — | IC90 | - | — | - | |
| CHEMBL4126846 | — | IC90 | - | — | - | |
| CHEMBL4128223 | — | IC90 | = | 14030.0 | nM | - |
| CHEMBL4128616 | — | IC90 | = | 3600.0 | nM | - |
| CHEMBL4127236 | — | IC90 | = | 14030.0 | nM | - |
| CHEMBL4127374 | — | IC90 | - | — | - |