Assay Detail
Binding
CHEMBL4123982
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Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Dengue virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.41 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4125966 | — | — | 1 | 6.19 |
| CHEMBL4127092 | — | — | 1 | 5.80 |
| CHEMBL4127819 | — | — | 1 | 5.70 |
| CHEMBL4127565 | — | — | 1 | 5.55 |
| CHEMBL521487 | — | — | 1 | 5.30 |
| CHEMBL4127030 | ADAFOSBUVIR 5'-TRIPHOSPHATE | -1.0 | 1 | 5.18 |
| CHEMBL4127921 | — | — | 1 | 4.80 |
| CHEMBL486231 | GS-461203 | -1.0 | 1 | 4.75 |
| CHEMBL4129313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4125966 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4127092 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4127819 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4127565 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL521487 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4127030 | ADAFOSBUVIR 5'-TRIPHOSPHATE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4127921 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL486231 | GS-461203 | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4129313 | — | IC50 | > | 20000.0 | nM | - |