Assay Detail
Binding
CHEMBL4124009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated for 60 mins followed by substrate addition measured after 4 hrs Topcount method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.79 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4127656 | — | — | 1 | 9.00 |
| CHEMBL4126996 | — | — | 1 | 9.00 |
| CHEMBL4128368 | — | — | 1 | 8.70 |
| CHEMBL4129721 | — | — | 1 | 8.34 |
| CHEMBL4126284 | — | — | 1 | 8.30 |
| CHEMBL4128640 | — | — | 1 | 8.30 |
| CHEMBL4127256 | — | — | 1 | 8.30 |
| CHEMBL4126014 | — | — | 1 | 8.30 |
| CHEMBL4127399 | — | — | 1 | 8.30 |
| CHEMBL4129859 | — | — | 1 | 8.30 |
| CHEMBL4126429 | — | — | 1 | 8.30 |
| CHEMBL4127131 | — | — | 1 | 8.30 |
| CHEMBL4126956 | — | — | 1 | 8.30 |
| CHEMBL4126816 | — | — | 1 | 8.30 |
| CHEMBL4129428 | — | — | 1 | 8.30 |
| CHEMBL4128495 | — | — | 1 | 8.22 |
| CHEMBL4127240 | — | — | 1 | 8.21 |
| CHEMBL4128621 | — | — | 1 | 7.77 |
| CHEMBL4128197 | — | — | 1 | 7.75 |
| CHEMBL4127385 | — | — | 1 | 7.68 |
| CHEMBL4128449 | — | — | 1 | 7.62 |
| CHEMBL4125765 | — | — | 1 | 7.47 |
| CHEMBL4127378 | — | — | 1 | 7.41 |
| CHEMBL4127969 | — | — | 1 | 7.38 |
| CHEMBL4129703 | — | — | 1 | 7.38 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.32 |
| CHEMBL4125996 | — | — | 1 | 7.24 |
| CHEMBL4125902 | — | — | 1 | 7.07 |
| CHEMBL4129210 | — | — | 1 | 7.00 |
| CHEMBL4129355 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4127656 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4126996 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4128368 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4129721 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4126284 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4128640 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4127256 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4126014 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4127399 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4129859 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4126429 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4127131 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4126956 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4126816 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4129428 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4128495 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4127240 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4128621 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4128197 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4127385 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4128449 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4125765 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4127378 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4127969 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4129703 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4125996 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4125902 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4129210 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4129355 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4126412 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4126731 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4128105 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4130227 | — | IC50 | = | 17.0 | nM | - |