Assay Detail
Functional
CHEMBL4124263
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced nitric oxide production preincubated for 2 hrs followed by LPS challenge measured after 24 hrs by Griess reagent based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hexahydrobenzophenanthridine alkaloids from Corydalis bungeana Turcz. and their anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.35 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4130075 | — | — | 1 | 6.00 |
| CHEMBL1209678 | CHEILANTHIFOLINE | — | 1 | 5.73 |
| CHEMBL4126232 | — | — | 1 | 5.69 |
| CHEMBL4127605 | — | — | 1 | 5.66 |
| CHEMBL4129364 | — | — | 1 | 5.65 |
| CHEMBL4126384 | — | — | 1 | 5.60 |
| CHEMBL4128383 | — | — | 1 | 5.55 |
| CHEMBL4129674 | — | — | 1 | 4.64 |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | 4.50 |
| CHEMBL4127010 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4130075 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1209678 | CHEILANTHIFOLINE | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4126232 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4127605 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4129364 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4126384 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4128383 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL4129674 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 31280.0 | nM | 4.50 |
| CHEMBL4127010 | — | IC50 | = | 33800.0 | nM | 4.47 |