Assay Detail
ADMET
CHEMBL4124289
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Antiproliferative activity against human HEK293 cells by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
lH-Pyrazolo[3,4-b]quinolin-3-amine derivatives inhibit growth of colon cancer cells via apoptosis and sub G1 cell cycle arrest.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.29 | 4.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4126709 | — | — | 1 | 4.44 |
| CHEMBL1688535 | — | — | 1 | 4.34 |
| CHEMBL4126209 | — | — | 1 | 4.09 |
| CHEMBL1369953 | — | — | 1 | - |
| CHEMBL15221 | — | — | 1 | - |
| CHEMBL1613444 | — | — | 1 | - |
| CHEMBL4127432 | — | — | 1 | - |
| CHEMBL4127746 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4126709 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL1688535 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL4126209 | — | IC50 | = | 81100.0 | nM | 4.09 |
| CHEMBL1369953 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL15221 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1613444 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4127432 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4127746 | — | IC50 | > | 100000.0 | nM | - |