Assay Detail
Functional
CHEMBL4124801
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Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 9.56 | 10.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4126027 | — | — | 1 | 10.81 |
| CHEMBL4126953 | — | — | 1 | 10.56 |
| CHEMBL4126738 | — | — | 1 | 10.54 |
| CHEMBL4130148 | — | — | 1 | 8.51 |
| CHEMBL4130044 | — | — | 1 | 7.37 |
| CHEMBL5314341 | GLUCAGON | 4.0 | 1 | - |
| CHEMBL414357 | EXENATIDE | 4.0 | 1 | - |
| CHEMBL4128125 | — | — | 1 | - |
| CHEMBL4128276 | — | — | 1 | - |
| CHEMBL4524066 | — | — | 1 | - |
| CHEMBL4127525 | — | — | 1 | - |
| CHEMBL4129347 | — | — | 1 | - |
| CHEMBL4130225 | — | — | 1 | - |
| CHEMBL4128194 | — | — | 1 | - |
| CHEMBL4126812 | — | — | 1 | - |
| CHEMBL4128112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4126027 | — | EC50 | = | 0.0154 | nM | 10.81 |
| CHEMBL4126953 | — | EC50 | = | 0.0276 | nM | 10.56 |
| CHEMBL4126738 | — | EC50 | = | 0.029 | nM | 10.54 |
| CHEMBL4130148 | — | EC50 | = | 3.09 | nM | 8.51 |
| CHEMBL4130044 | — | EC50 | = | 42.9 | nM | 7.37 |
| CHEMBL5314341 | GLUCAGON | EC50 | = | 0.0005 | nM | - |
| CHEMBL414357 | EXENATIDE | EC50 | > | 1.0 | 10'8pM | - |
| CHEMBL4128125 | — | EC50 | = | 0.0007 | nM | - |
| CHEMBL4128276 | — | EC50 | > | 1.0 | 10'8pM | - |
| CHEMBL4524066 | — | EC50 | > | 1.0 | 10'8pM | - |
| CHEMBL4127525 | — | EC50 | = | 0.0019 | nM | - |
| CHEMBL4129347 | — | EC50 | = | 0.0067 | nM | - |
| CHEMBL4130225 | — | EC50 | = | 0.0044 | nM | - |
| CHEMBL4128194 | — | EC50 | = | 0.0016 | nM | - |
| CHEMBL4126812 | — | EC50 | = | 0.0025 | nM | - |
| CHEMBL4128112 | — | EC50 | > | 1.0 | 10'8pM | - |