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Assay Detail

CHEMBL4124869

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Yellow fever virus infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathicity
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Yellow fever virus
Cell Type Vero
Confidence 1 — Organism
Curated By Intermediate

Target

Yellow fever virus (CHEMBL613731)
Type ORGANISM
Organism Yellow fever virus

Publication

Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
Pileggi E, Serpi M, Andrei G, Schols D, Snoeck R, Pertusati F.
Bioorg Med Chem (2018) 26 : 3596 -3609
PubMed 29880251 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 4.82 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 5.40
CHEMBL4127918 1 4.24
CHEMBL4126212 1 -
CHEMBL4128569 1 -
CHEMBL4127182 1 -
CHEMBL4129784 1 -
CHEMBL4128419 1 -
CHEMBL4126084 1 -
CHEMBL4129391 1 -
CHEMBL4128997 1 -
CHEMBL4127582 1 -
CHEMBL4127759 1 -
CHEMBL4129158 1 -
CHEMBL4126524 1 -
CHEMBL4129955 1 -
CHEMBL4126683 1 -
CHEMBL1643 RIBAVIRIN 4.0 1 -
CHEMBL4125717 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL866 MYCOPHENOLIC ACID EC50 = 4000.0 nM 5.40
CHEMBL4127918 EC50 = 58000.0 nM 4.24
CHEMBL4126212 EC50 > 100000.0 nM -
CHEMBL4128569 EC50 > 100000.0 nM -
CHEMBL4127182 EC50 > 100000.0 nM -
CHEMBL4129784 EC50 > 100000.0 nM -
CHEMBL4128419 EC50 > 100000.0 nM -
CHEMBL4126084 EC50 > 100000.0 nM -
CHEMBL4129391 EC50 > 100000.0 nM -
CHEMBL4128997 EC50 > 100000.0 nM -
CHEMBL4127582 EC50 > 100000.0 nM -
CHEMBL4127759 EC50 > 100000.0 nM -
CHEMBL4129158 EC50 > 100000.0 nM -
CHEMBL4126524 EC50 > 100000.0 nM -
CHEMBL4129955 EC50 > 100000.0 nM -
CHEMBL4126683 EC50 > 100000.0 nM -
CHEMBL1643 RIBAVIRIN EC50 > 250000.0 nM -
CHEMBL4125717 EC50 > 100000.0 nM -