Assay Detail
Functional
CHEMBL4125205
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Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.28 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.82 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 7.16 |
| CHEMBL4126080 | — | — | 1 | 7.14 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 7.07 |
| CHEMBL4126503 | — | — | 1 | 7.00 |
| CHEMBL3125599 | — | — | 1 | 6.75 |
| CHEMBL1672002 | THYMOQUINONE | 2.0 | 1 | 6.52 |
| CHEMBL4127468 | — | — | 1 | 6.25 |
| CHEMBL470981 | EGONOL | — | 1 | 4.61 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 4.43 |
| CHEMBL4128708 | — | — | 1 | 4.36 |
| CHEMBL3634694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL361497 | ARTESUNATE | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4126080 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL307261 | ARTENIMOL | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4126503 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3125599 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1672002 | THYMOQUINONE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4127468 | — | EC50 | = | 568.0 | nM | 6.25 |
| CHEMBL470981 | EGONOL | EC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL4128708 | — | EC50 | = | 43680.0 | nM | 4.36 |
| CHEMBL3634694 | — | EC50 | - | — | - |