Assay Detail
Binding
CHEMBL4125329
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Inhibition of tubulin (unknown origin) polymerization preincubated for 15 mins followed by GTP addition measured for 20 mins by turbidimetric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.04 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278779 | KOKUSAGININE | — | 1 | 6.09 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278779 | KOKUSAGININE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1020.0 | nM | 5.99 |