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Assay Detail

CHEMBL4132211

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of QD-labeled amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by inverted fluorescence microscopic method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties.
Taguchi R, Hatayama K, Takahashi T, Hayashi T, Sato Y, Sato D, Ohta K, Nakano H, Seki C, Endo Y, Tokuraku K, Uwai K.
Eur J Med Chem (2017) 138 : 1066 -1075
PubMed 28759879 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 25 4.80 5.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2088769 1 5.59
CHEMBL4165903 1 5.55
CHEMBL496662 HEXYLCAFFEATE 1 5.29
CHEMBL4176478 1 5.23
CHEMBL4169299 1 5.10
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER 1 5.08
CHEMBL496492 1 5.02
CHEMBL118111 1 4.98
CHEMBL4162671 1 4.94
CHEMBL29489 BUTYL CAFFEATE 1 4.92
CHEMBL3357165 1 4.83
CHEMBL1088583 1 4.69
CHEMBL324842 ROSMARINIC ACID 1 4.69
CHEMBL4170161 1 4.66
CHEMBL481891 1 4.63
CHEMBL17362 1 4.61
CHEMBL4164790 1 4.40
CHEMBL4159496 1 4.26
CHEMBL17001 METHYLCAFFEATE 1 4.17
CHEMBL68132 1 4.16
CHEMBL4167402 1 4.10
CHEMBL493921 PHENETHYL CINNAMATE 1 -
CHEMBL4162421 1 -
CHEMBL145 CAFFEIC ACID 3.0 1 -
CHEMBL4166279 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2088769 EC50 = 2580.0 nM 5.59
CHEMBL4165903 EC50 = 2820.0 nM 5.55
CHEMBL496662 HEXYLCAFFEATE EC50 = 5130.0 nM 5.29
CHEMBL4176478 EC50 = 5930.0 nM 5.23
CHEMBL4169299 EC50 = 7950.0 nM 5.10
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER EC50 = 8410.0 nM 5.08
CHEMBL496492 EC50 = 9520.0 nM 5.02
CHEMBL118111 EC50 = 10400.0 nM 4.98
CHEMBL4162671 EC50 = 11400.0 nM 4.94
CHEMBL29489 BUTYL CAFFEATE EC50 = 12000.0 nM 4.92
CHEMBL3357165 EC50 = 14900.0 nM 4.83
CHEMBL1088583 EC50 = 20600.0 nM 4.69
CHEMBL324842 ROSMARINIC ACID EC50 = 20300.0 nM 4.69
CHEMBL4170161 EC50 = 21900.0 nM 4.66
CHEMBL481891 EC50 = 23200.0 nM 4.63
CHEMBL17362 EC50 = 24700.0 nM 4.61
CHEMBL4164790 EC50 = 39500.0 nM 4.40
CHEMBL4159496 EC50 = 54800.0 nM 4.26
CHEMBL17001 METHYLCAFFEATE EC50 = 67700.0 nM 4.17
CHEMBL68132 EC50 = 69000.0 nM 4.16
CHEMBL4167402 EC50 = 80100.0 nM 4.10
CHEMBL493921 PHENETHYL CINNAMATE EC50 = 1040000.0 nM -
CHEMBL4162421 EC50 = 4536000.0 nM -
CHEMBL145 CAFFEIC ACID EC50 = 216000.0 nM -
CHEMBL4166279 EC50 = 274000.0 nM -