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Assay Detail

CHEMBL4132271

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against blood stream form of Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 72 hrs by Alamar Blue assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines.
Papadopoulou MV, Bloomer WD, Rosenzweig HS, Kaiser M.
Eur J Med Chem (2017) 138 : 1106 -1113
PubMed 28763645 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.16 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL166 MELARSOPROL 3.0 1 8.10
CHEMBL4177234 1 7.42
CHEMBL1922441 1 6.71
CHEMBL1922440 1 6.51
CHEMBL4168552 1 6.41
CHEMBL4171905 1 5.90
CHEMBL4164033 1 5.89
CHEMBL1922429 1 5.85
CHEMBL1922430 1 5.73
CHEMBL4160631 1 5.59
CHEMBL4165130 1 4.88
CHEMBL4166614 1 4.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL166 MELARSOPROL IC50 = 8.0 nM 8.10
CHEMBL4177234 IC50 = 38.0 nM 7.42
CHEMBL1922441 IC50 = 193.0 nM 6.71
CHEMBL1922440 IC50 = 309.0 nM 6.51
CHEMBL4168552 IC50 = 390.0 nM 6.41
CHEMBL4171905 IC50 = 1270.0 nM 5.90
CHEMBL4164033 IC50 = 1290.0 nM 5.89
CHEMBL1922429 IC50 = 1400.0 nM 5.85
CHEMBL1922430 IC50 = 1870.0 nM 5.73
CHEMBL4160631 IC50 = 2580.0 nM 5.59
CHEMBL4165130 IC50 = 13200.0 nM 4.88
CHEMBL4166614 IC50 = 13500.0 nM 4.87