Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4132275

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 2 days by cell-titer-glo luminescent assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Intermediate

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines.
Papadopoulou MV, Bloomer WD, Rosenzweig HS, Kaiser M.
Eur J Med Chem (2017) 138 : 1106 -1113
PubMed 28763645 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.46 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4160631 1 5.05
CHEMBL1922429 1 4.60
CHEMBL4168552 1 4.46
CHEMBL4171905 1 4.44
CHEMBL4166614 1 4.42
CHEMBL4165130 1 4.41
CHEMBL1922430 1 4.17
CHEMBL4177234 1 4.13
CHEMBL4164033 1 -
CHEMBL1922440 1 -
CHEMBL1922441 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4160631 IC50 = 8960.0 nM 5.05
CHEMBL1922429 IC50 = 25000.0 nM 4.60
CHEMBL4168552 IC50 = 34400.0 nM 4.46
CHEMBL4171905 IC50 = 36200.0 nM 4.44
CHEMBL4166614 IC50 = 37700.0 nM 4.42
CHEMBL4165130 IC50 = 38600.0 nM 4.41
CHEMBL1922430 IC50 = 66800.0 nM 4.17
CHEMBL4177234 IC50 = 73600.0 nM 4.13
CHEMBL4164033 IC50 = 107000.0 nM -
CHEMBL1922440 IC50 = 143000.0 nM -
CHEMBL1922441 IC50 = 137000.0 nM -