Assay Detail
Functional
CHEMBL4132278
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Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 expressing luxABCDE operon incubated for 10 days under hypoxic conditions followed by incubation under aerobic conditions for 28 hrs by LORA method
21
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.34 | 9.14 |
| IC90 | 7 | - | - |
| MIC | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 3 | 9.14 |
| CHEMBL4171905 | — | — | 3 | 6.82 |
| CHEMBL4168552 | — | — | 3 | 4.96 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 3 | 4.44 |
| CHEMBL4160631 | — | — | 3 | - |
| CHEMBL4164033 | — | — | 3 | - |
| CHEMBL4177234 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4171905 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4168552 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4164033 | — | IC50 | - | — | - | |
| CHEMBL4177234 | — | IC50 | - | — | - | |
| CHEMBL4160631 | — | IC90 | - | — | - | |
| CHEMBL4168552 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL4164033 | — | IC90 | - | — | - | |
| CHEMBL4171905 | — | IC90 | = | 840.0 | nM | - |
| CHEMBL4177234 | — | IC90 | - | — | - | |
| CHEMBL374478 | RIFAMPIN | IC90 | = | 3.7 | nM | - |
| CHEMBL137 | METRONIDAZOLE | IC90 | = | 82000.0 | nM | - |
| CHEMBL4160631 | — | MIC | = | 9180.0 | nM | - |
| CHEMBL4168552 | — | MIC | > | 100000.0 | nM | - |
| CHEMBL4164033 | — | MIC | = | 2890.0 | nM | - |
| CHEMBL4171905 | — | MIC | = | 4140.0 | nM | - |
| CHEMBL4177234 | — | MIC | > | 100000.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | MIC | = | 22.0 | nM | - |
| CHEMBL4160631 | — | IC50 | - | — | - | |
| CHEMBL137 | METRONIDAZOLE | MIC | = | 200000.0 | nM | - |