Assay Detail
Functional
CHEMBL4132614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Puromycin based inhibitors of aminopeptidases for the potential treatment of hematologic malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.50 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.26 |
| CHEMBL3244799 | — | — | 1 | 6.72 |
| CHEMBL4161496 | — | — | 1 | 6.39 |
| CHEMBL2103847 | TOSEDOSTAT | 2.0 | 1 | 5.33 |
| CHEMBL4169814 | — | — | 1 | 5.00 |
| CHEMBL3244800 | — | — | 1 | 4.50 |
| CHEMBL4161892 | — | — | 1 | 4.47 |
| CHEMBL4173240 | — | — | 1 | 4.34 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | - |
| CHEMBL4165328 | — | — | 1 | - |
| CHEMBL4161744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469912 | PUROMYCIN | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3244799 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4161496 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2103847 | TOSEDOSTAT | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4169814 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3244800 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4161892 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4173240 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL29292 | UBENIMEX | EC50 | > | 100000.0 | nM | - |
| CHEMBL4165328 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4161744 | — | EC50 | > | 100000.0 | nM | - |