Assay Detail
Binding
CHEMBL4132701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full-length 11beta-HSD2 expressed in HEK293 cells using cortisol as substrate after 2 hrs by LC-MS analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL3746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.67 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160328 | — | — | 1 | 7.00 |
| CHEMBL4170932 | — | — | 1 | 7.00 |
| CHEMBL4170544 | — | — | 1 | 6.00 |
| CHEMBL4163698 | — | — | 1 | - |
| CHEMBL4174368 | — | — | 1 | - |
| CHEMBL4162610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160328 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4170932 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4170544 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4163698 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4174368 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4162610 | — | IC50 | < | 100.0 | nM | - |