Assay Detail
Functional
CHEMBL4132769
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Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel methyl indolinone-6-carboxylates containing an indole moiety as angiokinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.95 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164318 | — | — | 1 | 6.89 |
| CHEMBL4162400 | — | — | 1 | 6.60 |
| CHEMBL4173756 | — | — | 1 | 6.50 |
| CHEMBL4172205 | — | — | 1 | 6.34 |
| CHEMBL4177112 | — | — | 1 | 6.16 |
| CHEMBL502835 | NINTEDANIB | 4.0 | 1 | 6.08 |
| CHEMBL4165850 | — | — | 1 | 6.06 |
| CHEMBL4165827 | — | — | 1 | 6.01 |
| CHEMBL4166696 | — | — | 1 | 5.96 |
| CHEMBL4165429 | — | — | 1 | 5.93 |
| CHEMBL4161991 | — | — | 1 | 5.66 |
| CHEMBL4173078 | — | — | 1 | 5.17 |
| CHEMBL4169257 | — | — | 1 | 4.05 |
| CHEMBL4163106 | — | — | 1 | - |
| CHEMBL4176039 | — | — | 1 | - |
| CHEMBL4176458 | — | — | 1 | - |
| CHEMBL4161351 | — | — | 1 | - |
| CHEMBL4173817 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164318 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4162400 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4173756 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4172205 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4177112 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL502835 | NINTEDANIB | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4165850 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4165827 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4166696 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4165429 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4161991 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4173078 | — | IC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL4169257 | — | IC50 | = | 89870.0 | nM | 4.05 |
| CHEMBL4163106 | — | IC50 | - | — | - | |
| CHEMBL4176039 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4176458 | — | IC50 | - | — | - | |
| CHEMBL4161351 | — | IC50 | - | — | - | |
| CHEMBL4173817 | — | IC50 | - | — | - |