Compound Detail
CHEMBL4173817
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COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2nc(CN3CCN(C)CC3)oc2c1)c1ccccc1
Basic Information
| ChEMBL ID | CHEMBL4173817 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RVEYJKXPSJYNGG-DQSJHHFOSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
523.6
MW (Da)
4.29
ALogP
8
HBA
2
HBD
99.9
PSA (Ų)
0.29
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 6.93 | 6.93 | 116.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 116.2 | nM | 6.93 | Inhibition of N-terminal GST tagged human PDGFRbeta (557 to 1106 end residues) c... | 28826084 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28826084 | 10.1016/j.ejmech.2017.08.031 | Vascular endothelial growth factor receptor 2 | 1 |
| 28826084 | 10.1016/j.ejmech.2017.08.031 | Platelet-derived growth factor receptor beta | 1 |
| 28826084 | 10.1016/j.ejmech.2017.08.031 | A549 | 1 |
| 28826084 | 10.1016/j.ejmech.2017.08.031 | MCF7 | 1 |
| 28826084 | 10.1016/j.ejmech.2017.08.031 | HT-29 | 1 |
Data from ChEMBL 36 via Core Engine