Assay Detail
Functional
CHEMBL4132831
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Antiviral activity against HIV1 infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 5 days by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.70 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170852 | — | — | 1 | 7.14 |
| CHEMBL4174284 | — | — | 1 | 7.06 |
| CHEMBL4163603 | — | — | 1 | 7.00 |
| CHEMBL4159355 | — | — | 1 | 6.94 |
| CHEMBL4174119 | — | — | 1 | 6.92 |
| CHEMBL4160243 | — | — | 1 | 6.75 |
| CHEMBL4172794 | — | — | 1 | 6.49 |
| CHEMBL2170300 | — | — | 1 | 6.44 |
| CHEMBL4169092 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170852 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4174284 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4163603 | — | EC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4159355 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4174119 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4160243 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4172794 | — | EC50 | = | 325.0 | nM | 6.49 |
| CHEMBL2170300 | — | EC50 | = | 362.0 | nM | 6.44 |
| CHEMBL4169092 | — | EC50 | = | 2510.0 | nM | 5.60 |