Assay Detail
Functional
CHEMBL4133040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity in rat thoracic aorta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel rhynchophylline analogues as microvascular relaxation agents for the treatment of microvascular dysfunction caused by diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.79 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172138 | — | — | 1 | 6.70 |
| CHEMBL4164257 | — | — | 1 | 5.43 |
| CHEMBL4168427 | — | — | 1 | 5.23 |
| CHEMBL1668786 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172138 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL4164257 | — | IC50 | = | 3686.0 | nM | 5.43 |
| CHEMBL4168427 | — | IC50 | = | 5891.0 | nM | 5.23 |
| CHEMBL1668786 | — | IC50 | = | 174200.0 | nM | - |