Assay Detail
Functional
CHEMBL4133041
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Vasorelaxant activity in Sprague-Dawley rat endothelium intact mesentric artery rings assessed as inhibition of phenylephrine-induced contraction
9
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Mesenteric artery |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel rhynchophylline analogues as microvascular relaxation agents for the treatment of microvascular dysfunction caused by diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Emax | 3 | - | - |
| IC50 | 3 | 6.15 | 7.04 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172138 | — | — | 3 | 7.04 |
| CHEMBL4168427 | — | — | 3 | 6.30 |
| CHEMBL4164257 | — | — | 3 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172138 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4168427 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL4164257 | — | IC50 | = | 7790.0 | nM | 5.11 |
| CHEMBL4168427 | — | Emax | = | 99.88 | % | - |
| CHEMBL4172138 | — | Emax | = | 100.12 | % | - |
| CHEMBL4164257 | — | Emax | = | 99.06 | % | - |
| CHEMBL4168427 | — | Inhibition | - | % | - | |
| CHEMBL4172138 | — | Inhibition | - | % | - | |
| CHEMBL4164257 | — | Inhibition | - | % | - |