Assay Detail
Functional
CHEMBL4133043
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Vasorelaxant activity in Sprague-Dawley rat endothelium denuded mesentric artery rings assessed as inhibition of phenylephrine-induced contraction
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Mesenteric artery |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel rhynchophylline analogues as microvascular relaxation agents for the treatment of microvascular dysfunction caused by diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.17 | 5.92 |
| Emax | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168427 | — | — | 2 | 5.92 |
| CHEMBL4172138 | — | — | 2 | 5.29 |
| CHEMBL4164257 | — | — | 2 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168427 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4172138 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL4164257 | — | IC50 | = | 49890.0 | nM | 4.30 |
| CHEMBL4168427 | — | Emax | = | 99.74 | % | - |
| CHEMBL4172138 | — | Emax | = | 100.76 | % | - |
| CHEMBL4164257 | — | Emax | = | 86.29 | % | - |