Assay Detail
Functional
CHEMBL4133217
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Antiinflammatory activity in ICR mouse primary peritoneal macrophages assessed as inhibition of LPS-induced TNF-alpha production pretreated for 2 hrs followed by LPS challenge measured after 22 hrs by ELISA
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Peritoneal macrophage |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 3 | - | - |
| IC50 | 3 | 5.43 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164940 | — | — | 2 | 5.53 |
| CHEMBL4176576 | — | — | 2 | 5.43 |
| CHEMBL4162528 | — | — | 2 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164940 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL4176576 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL4162528 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4176576 | — | Inhibition | - | % | - | |
| CHEMBL4162528 | — | Inhibition | - | % | - | |
| CHEMBL4164940 | — | Inhibition | - | % | - |