Assay Detail
Functional
CHEMBL4134221
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Ex-vivo inhibition of PI3Kdelta in po dosed cynomolgus monkey assessed as reduction in anti-IgM-induced AKT phosphorylation at ser473 residue in whole blood pretreated up to 24 hrs followed by anti-IgM stimulation after 20 mins by flow cytometric analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Macaca fascicularis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.08 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | 4.0 | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | IC50 | = | 84.0 | nM | 7.08 |