Assay Detail
Functional
CHEMBL4134269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ex-vivo inhibition of PI3Kdelta in po dosed Lewis rat assessed as reduction in anti-IgM/IL4-induced AKT phosphorylation at ser473 residue in whole blood pretreated up to 24 hrs followed by anti-IgM/IL4 stimulation after 10 mins by flow cytometric analysis
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| fEC50 | 1 | - | - |
| EC50 | 1 | 7.08 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | 4.0 | 2 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3643413 | LENIOLISIB | fEC50 | = | 5.0 | nM | - |