Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4134307

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

C-C chemokine receptor type 4 (CHEMBL2414) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.
Kindon N, Andrews G, Baxter A, Cheshire D, Hemsley P, Johnson T, Liu YZ, McGinnity D, McHale M, Mete A, Reuberson J, Roberts B, Steele J, Teobald B, Unitt J, Vaughan D, Walters I, Stocks MJ.
ACS Med Chem Lett (2017) 8 : 981 -986
PubMed 28947948 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 7.13 9.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4172769 — — 1 9.50
CHEMBL4167445 — — 1 9.20
CHEMBL4162364 — — 1 9.00
CHEMBL4172635 — — 1 8.60
CHEMBL4160218 — — 1 8.60
CHEMBL4175323 — — 1 8.40
CHEMBL4173046 — — 1 8.40
CHEMBL4160846 — — 1 8.40
CHEMBL4173861 — — 1 8.10
CHEMBL4165356 — — 1 8.10
CHEMBL4170431 — — 1 8.00
CHEMBL4162097 — — 1 7.90
CHEMBL4175972 — — 1 7.90
CHEMBL4165939 — — 1 7.90
CHEMBL4169247 — — 1 7.80
CHEMBL4162555 — — 1 7.80
CHEMBL4170833 — — 1 7.80
CHEMBL4164738 — — 1 7.70
CHEMBL4168237 — — 1 7.70
CHEMBL4168775 — — 1 7.60
CHEMBL4160139 — — 1 7.40
CHEMBL4172568 — — 1 7.40
CHEMBL4160463 — — 1 7.40
CHEMBL4164247 — — 1 7.30
CHEMBL4171579 — — 1 7.20
CHEMBL4160965 — — 1 7.20
CHEMBL2011441 — — 1 7.20
CHEMBL4176082 — — 1 7.10
CHEMBL4166246 — — 1 7.00
CHEMBL4159115 — — 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4172769 — IC50 = 0.3162 nM 9.50
CHEMBL4167445 — IC50 = 0.631 nM 9.20
CHEMBL4162364 — IC50 = 1.0 nM 9.00
CHEMBL4172635 — IC50 = 2.512 nM 8.60
CHEMBL4160218 — IC50 = 2.512 nM 8.60
CHEMBL4175323 — IC50 = 3.981 nM 8.40
CHEMBL4173046 — IC50 = 3.981 nM 8.40
CHEMBL4160846 — IC50 = 3.981 nM 8.40
CHEMBL4173861 — IC50 = 7.943 nM 8.10
CHEMBL4165356 — IC50 = 7.943 nM 8.10
CHEMBL4170431 — IC50 = 10.0 nM 8.00
CHEMBL4162097 — IC50 = 12.59 nM 7.90
CHEMBL4175972 — IC50 = 12.59 nM 7.90
CHEMBL4165939 — IC50 = 12.59 nM 7.90
CHEMBL4170833 — IC50 = 15.85 nM 7.80
CHEMBL4162555 — IC50 = 15.85 nM 7.80
CHEMBL4169247 — IC50 = 15.85 nM 7.80
CHEMBL4164738 — IC50 = 19.95 nM 7.70
CHEMBL4168237 — IC50 = 19.95 nM 7.70
CHEMBL4168775 — IC50 = 25.12 nM 7.60
CHEMBL4160139 — IC50 = 39.81 nM 7.40
CHEMBL4172568 — IC50 = 39.81 nM 7.40
CHEMBL4160463 — IC50 = 39.81 nM 7.40
CHEMBL4164247 — IC50 = 50.12 nM 7.30
CHEMBL2011441 — IC50 = 63.1 nM 7.20
CHEMBL4160965 — IC50 = 63.1 nM 7.20
CHEMBL4171579 — IC50 = 63.1 nM 7.20
CHEMBL4176082 — IC50 = 79.43 nM 7.10
CHEMBL4166246 — IC50 = 100.0 nM 7.00
CHEMBL4159115 — IC50 = 125.89 nM 6.90
CHEMBL4176859 — IC50 = 125.89 nM 6.90
CHEMBL4176441 — IC50 = 158.49 nM 6.80
CHEMBL4167390 — IC50 = 158.49 nM 6.80
CHEMBL4165500 — IC50 = 199.53 nM 6.70
CHEMBL4162503 — IC50 = 199.53 nM 6.70
CHEMBL4174254 — IC50 = 630.96 nM 6.20
CHEMBL4174488 — IC50 = 630.96 nM 6.20
CHEMBL4175259 — IC50 = 794.33 nM 6.10
CHEMBL4170786 — IC50 = 1000.0 nM 6.00
CHEMBL4161268 — IC50 = 1000.0 nM 6.00
CHEMBL4171873 — IC50 = 1258.93 nM 5.90
CHEMBL4174872 — IC50 = 3162.28 nM 5.50
CHEMBL4173424 — IC50 = 3162.28 nM 5.50
CHEMBL4163571 — IC50 = 3162.28 nM 5.50
CHEMBL4165828 — IC50 = 5011.87 nM 5.30
CHEMBL4161922 — IC50 = 5011.87 nM 5.30
CHEMBL4167021 — IC50 = 5011.87 nM 5.30
CHEMBL4169258 — IC50 = 7943.28 nM 5.10
CHEMBL4168920 — IC50 = 10000.0 nM 5.00
CHEMBL4166980 — IC50 > 10000.0 nM -