Assay Detail
Binding
CHEMBL4134686
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Inhibition of C-terminal His-tagged human HDAC5 (656-1122 residues) expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mins by fluorescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.43 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3110004 | — | — | 1 | 6.00 |
| CHEMBL4166084 | — | — | 1 | 5.53 |
| CHEMBL4173338 | — | — | 1 | 4.77 |
| CHEMBL4169910 | — | — | 1 | - |
| CHEMBL4162637 | — | — | 1 | - |
| CHEMBL4176702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3110004 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4166084 | — | IC50 | = | 2967.0 | nM | 5.53 |
| CHEMBL4173338 | — | IC50 | = | 16840.0 | nM | 4.77 |
| CHEMBL4169910 | — | IC50 | - | — | - | |
| CHEMBL4162637 | — | IC50 | - | — | - | |
| CHEMBL4176702 | — | IC50 | - | — | - |